大腸癌原発巣および肝転移巣におけるＳＰａｎ‐１抗原の発現に関する検討

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  • Increased Expression of SPan-1 Antigen in Liver Metastases of Human Colorectal Carcinoma.

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Immunohistochemical methods were used to study the expression of SPan-1 antigen and CEA in both primary tumors and matched metastatic liver lesions of colorectal car-cinomas. Specimens from primary tumors and matched liver metastases from 24 patients with colorectal carcinomas were immunohistochemically studied. The expression of SPan-1 anitigen and CEA in liver metastases was compared to that in primary colorectal carci-nomas. The degree of expression of CEA on liver metastases was similar to that in prima-ry tumous, but that of SPan-1 antigen was expressed on a larger proportion of tumor cells in liver metastases than in primary tumors. The findings suggest that colorectal carcinoma cells expressing SPan-1 antigen form metastatic liver tumors. They also suggest that expression of SPan-1 antigen in primary colorectal carcinoma can be usesd as a prognostic indicator of metastasis.

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