光発癌

• 上田 正登

  神戸大学大学院医学系研究科応用分子医学講座皮膚科学

書誌事項

タイトル別名

• Molecular Mechanisms of Photocarcinogenesis
• 生涯教育講座 光発癌
• ショウガイ キョウイク コウザ ヒカリハツガン

抄録

The exposure of mammalian cells to ultraviolet radiation (UV) leads to DNA damage, resulting in mutation and possible cancer. UV irradiation has been shown to act both as a tumor initiator and as a tumor promoter. The initiation step by UV involves genetic changes in oncogenes and tumor suppressor genes such as ras, p53, and patched. p53 mutations can be detected in normal skin from sun-exposed sites, indicating the early event of multi-step carcinogenesis. Furthermore, the activation of telomerase may precede the p53 mutation. The molecular mechanisms of UV-induced tumor promotion, principally the epigenetic phenomenon, remain elusive. Molecules acting as tumor promoters in photocarcinogenes include PKC, free radicals, tumor necrosis factor-α, and cyclooxygenase-2. In addition, UV-induced apoptosis is deeply involved in tumor promotion, because resistance to apoptosis is closely associated with the acceleration of tumor formation. The roles of p 53, Fas/FasL, tumor necrosis factor-α, nerve growth factor, and DNA damage in UV-induced apoptosis are discussed.

収録刊行物

• 日本皮膚科学会雑誌

  日本皮膚科学会雑誌 111 (14), 2073-2080, 2001

  公益社団法人 日本皮膚科学会

キーワード

• UV
• initiation
• promotion
• apoptosis

詳細情報

• CRID: 1390001205739037568
• NII論文ID: 10007909471
• NII書誌ID: AN00196602
• DOI: 10.14924/dermatol.111.2073
• ISSN: 13468146
• ISSN: 0021499X
• NDL書誌ID: 025121632
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I025121632
• Web Site: https://search.jamas.or.jp/link/ui/2002114444
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可