８歳で発症したナルコレプシーの１例

• 塚本 東子

  名古屋市立大学医学部小児科

• 石川 達也

  名古屋市立大学医学部小児科

• 張 尚美

  名古屋市立大学医学部小児科

• 水野 久美子

  名古屋市立大学医学部病院中央臨床検査部

書誌事項

タイトル別名

• Narcolepsy in a Prepubertal Boy.

抄録

We reported a 10-year-old boy with narcolepsy, the onset of which was at the age of 8 years and 6 months. The initial symptom was excessive daytime sleepiness, followed by cataplexy and disrupted nocturnal sleep. There was neither hallucination nor sleep paralysis. A daytime polysomnogram showed a sleeponset rapid eye movement period (SOREMP), and human leukocyte antigen (HLA) analysis revealed HLA-DR2/DQB1*0602. Treatment with methylphenidate and clomipramine was effective; methylphenidate (30mg/day) improved his wakefulness and alertness throughout the day, and clomipramine (20mg/day) reduced the number of cataplexic episodes.<BR>Because of their abnormal behavior, prepubertal narcoleptic children may often be misdiagnosed as having epilepsy or an attention deficit hyperactivity disorder. Therefore, they need early diagnosis and treatment. Assistance should be provided to protect them from being labeled as lazy by their parents and school teachers.

収録刊行物

• 脳と発達

  脳と発達 33 (6), 523-527, 2001

  THE JAPANESE SOCIETY OF CHILD NEUROLOGY

キーワード

• ナルコレプシー
• 小児
• ヒト主要組織抗原 (HLA)
• 睡眠障害
• ヒポクレチン

詳細情報

• CRID: 1390282679529292032
• NII論文ID: 10007910800
• NII書誌ID: AN0020232X
• DOI: 10.11251/ojjscn1969.33.523
• ISSN: 18847668
• ISSN: 00290831
• PubMed: 11725521
• Web Site: https://search.jamas.or.jp/link/ui/2002065646
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可