Protective Effects of Hot Water Extract of Safflower Leaves and Its Component Luteolin-7-O-Glucoside on Paraquat-Induced Oxidative Stress in Rats

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著者

    • IGARASHI Kiharu
    • Department of Bioresource Engineering, Faculty of Agriculture, Yamagata University
    • DEMACHI Akiko
    • Department of Bioresource Engineering, Faculty of Agriculture, Yamagata University
    • TAKENAKA Asako
    • Department of Bioresource Engineering, Faculty of Agriculture, Yamagata University

抄録

Suppressive effects of hot water extract of safflower leaves (Ex) and its major component luteolin-7-O-glucoside (LuGlc) on oxidative stress were determined in rats in which oxidative stress had been induced by paraquat (PQ). Both Ex and LuGlc suppressed lowering of food intake, and body weight gain, increases in lung weight, liver thiobarbituric acid reactive substances (TBARS), and a decrease in the liver triacylglycerol concentration were all induced by PQ-feeding. Rises in the liver total glutathione and oxidized glutathione concentrations in the PQ-fed rats were suppressed by adding Ex and LuGlc to the PQ diet. Moreover, Ex and LuGlc tended to suppress decreases in catalase activity in the liver mitochondrial fraction and liver α-tocopherol concentration which were induced by PQ-feeding. These results showed that both Ex and LuGlc, which is a major component of Ex, may be available to suppress oxidative stress <i>in vivo</i>.<br>

収録刊行物

  • Food science and technology research

    Food science and technology research 7(3), 224-230, 2001-08-01

    Japanese Society for Food Science and Technology

参考文献:  30件中 1-30件 を表示

被引用文献:  4件中 1-4件 を表示

各種コード

  • NII論文ID(NAID)
    10008015977
  • NII書誌ID(NCID)
    AA11267620
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    13446606
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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