Quercetin Glucosides are Hydrolyzed to Quercetin in Human Oral Cavity to Participate in Peroxidase-Dependent Scavenging of Hydrogen Peroxide

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It has been reported that consuming food which contains flavonols is related to the decrease in risks to arteriosclerosis and cancer. One objective of this study was to elucidate the metabolism of quercetin and the glucosides (quercetin 3,4′-diglucoside and quercetin 4′-glucoside) present in onion soup, in the oral cavity. Not only quercetin glucosides but also quercetin were found in whole saliva which was collected 15 min after eating onion soup. Quercetin seemed to be formed by deglucosidation of the glucosides. The concentrations of the flavonols were much higher in sediments than in supernatants of the saliva suggesting that the flavonols bound to components of the sediments like detached epithelial cells. Concentrations of quercetin and the glucosides in the oral cavity decreased as a function of time after the intake. The decreases were mainly due to the washing away from this cavity by saliva. In addition, deglucosidation of quercetin glucosides to quercetin was also assumed to contribute to the decrease in the glucosides and oxidation of quercetin by peroxidase (POX) in saliva to the decrease in quercetin. Based on the data that quercetin was oxidized by POX in saliva in the presence and absence of thiocyanate, it is suggested that quercetin as well as thiocyanate can be a substrate for POX in saliva to scavenge H<sub>2</sub>O<sub>2</sub> in oral cavity.<br>

収録刊行物

  • Food science and technology research

    Food science and technology research 7(3), 239-245, 2001-08-01

    Japanese Society for Food Science and Technology

参考文献:  25件中 1-25件 を表示

被引用文献:  2件中 1-2件 を表示

各種コード

  • NII論文ID(NAID)
    10008016048
  • NII書誌ID(NCID)
    AA11267620
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    13446606
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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