ルブラトキシンＢはマウスに低血糖症と血清中のインターロイキン－6量の増加を引き起こす

• 長嶋　 等

  農林水産省食品総合研究所

• 中村 久美子

  農林水産省食品総合研究所

• 後藤 哲久

  農林水産省食品総合研究所

書誌事項

タイトル別名

• Rubratoxin B caused hypoglycemia and elevated serum interleukin-6 levels in mice.

抄録

In order to find serological marker(s) of rubratoxin B′s toxicity, the effects of rubratoxin B on serum transaminases, glucose, triglyceride, cholesterol, interleukin (IL) -1β, IL-6 and tumor necrosis factor (TNF) -α levels in mice were investigated. Serum transaminase levels of 24-hr rubratoxin B-treated C3H/HeN mice were much higher than controls, indicating that rubratoxin B brought about hepatic injury. However, rubratoxin B-caused elevation was not remarkable in BALB/cAnN mice. Rubratoxin B decreased serum glucose level in mice of both strains. Again, rubratoxin B was less effective in BALB/cAnN mice. Serum triglyceride and cholesterol levels were not affected by rubratoxin B. We observed drastic elevation of serum IL-6 level in 24-hr rubratoxin B-treated C3H/HeN mice. On the other hand, we detected virtually no serum IL-6 in BALB/cAnN mice. In addition, serum IL -1β and TNF -α were not detected in mice of both strains. Taken together the above results, rubratoxin B exerted more toxicity and induced much more serum IL-6 in C3H/HeN mice than in BALB/AnN mice. It is likely that IL-6 is an excellent serological marker of the toxicity of rubratoxin B. Our results suggest that rubratoxin B can serve as a good model of drug-induced hepatic injury.

収録刊行物

• マイコトキシン

  マイコトキシン 51 (1), 7-12, 2001

  日本マイコトキシン学会

キーワード

• ルブラトキシンB
• 肝障害
• IL-6

詳細情報

• CRID: 1390001204785243648
• NII論文ID: 10008018064
• NII書誌ID: AN00334513
• DOI: 10.2520/myco.51.7
• COI: 1:CAS:528:DC%2BD3MXisFKlur4%3D
• ISSN: 18810128
• ISSN: 02851466
• ISSN: http://id.crossref.org/issn/02851466
• Web Site: https://search.jamas.or.jp/link/ui/2001142630
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可