Gatifloxacin投与による健康成人糞便内細菌叢の変動

DOI 被引用文献1件 参考文献6件

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  • Effect of gatifloxacin on human fecal flora

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Gatifloxacin (GFLX) is a newly developed quinolone derivative. Fecal flora were studied in six healthy male volunteers after the oral administration of two doses of 300 mg of GFLX for seven days.Fecal samples were taken prior to and several times after administration, and quantitative and qualitative analyses of microorganisms in the feces were performed.<BR>Counts of aerobic and anaerobic bacteria were depressed during the administration period. Total bacterial counts decreased in two of the six volunteers.<BR>Fecal bacteria returned to their former levels within 14 days after administration.<BR>Transient appearance of Clostridium difficile was observed in two volunteers.

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