書誌事項
- タイトル別名
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- Absorption characteristics of gatifloxacin, a new quinolone, in rats
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The intestinal absorption characteristics of gatifloxacin (GFLX), a new fluoro-methoxy-quinolone, were investigated in rats using the in situ ligated loop method.<BR>1. GFLX was absorbed well from duodenum, jejunum, ileum, and colon, but not from the stomach.<BR>2. This drug was rapidly absorbed from jejunum and ileum, and tissue accumulation was minimal.<BR>3. The absorption of quinolones from jejunum loops increased with the increase of lipophilicity. GFLX was completely absorbed in the same manner as fleroxacin, ofloxacin, and sparfloxacin.<BR>4. The high concentrations of amino acids and peptides did not inhibit the absorption of GFLX from jejunum loops. On the other hand, the absorption of cephalexin, which was transferred by a dipeptide carrier-mediated system in the small intestine, was found to be inhibited by glycylglycine but not by glycine. This fact suggests that the common amino acid-or peptidemediated active transport system dose contribute to the absorption of GFLX in the small intestine.
収録刊行物
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- 日本化学療法学会雑誌
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日本化学療法学会雑誌 47 (Supplement2), 161-165, 1999
公益社団法人 日本化学療法学会
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詳細情報
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- CRID
- 1390282681266341504
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- NII論文ID
- 10008029095
- 130004297947
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- NII書誌ID
- AN10472127
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- ISSN
- 18845886
- 13407007
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可