新キノロン系抗菌薬gatifloxacinのラットにおける吸収特性

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  • Absorption characteristics of gatifloxacin, a new quinolone, in rats

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The intestinal absorption characteristics of gatifloxacin (GFLX), a new fluoro-methoxy-quinolone, were investigated in rats using the in situ ligated loop method.<BR>1. GFLX was absorbed well from duodenum, jejunum, ileum, and colon, but not from the stomach.<BR>2. This drug was rapidly absorbed from jejunum and ileum, and tissue accumulation was minimal.<BR>3. The absorption of quinolones from jejunum loops increased with the increase of lipophilicity. GFLX was completely absorbed in the same manner as fleroxacin, ofloxacin, and sparfloxacin.<BR>4. The high concentrations of amino acids and peptides did not inhibit the absorption of GFLX from jejunum loops. On the other hand, the absorption of cephalexin, which was transferred by a dipeptide carrier-mediated system in the small intestine, was found to be inhibited by glycylglycine but not by glycine. This fact suggests that the common amino acid-or peptidemediated active transport system dose contribute to the absorption of GFLX in the small intestine.

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