Hypoplastic Mixed Lineage Leukemia Successfully Treated with Low-dose Cytosine Arabinoside

• SASAKI Shin

  First Department of Internal Medicine

• UEDA Seiji

  First Department of Internal Medicine

• ASAKURA Yuusuke

  First Department of Internal Medicine

• YAMAZAKI Etsuko

  First Department of Internal Medicine

• KATO Kazunobu

  First Department of Internal Medicine

• TAGUCHI Jun

  First Department of Internal Medicine

• HARANO Hiroshi

  First Department of Internal Medicine

• KANAMORI Heiwa

  First Department of Internal Medicine

• OGAWA Koji

  First Department of Internal Medicine

• OTSUKA Mami

  Division of Transfusion Medicine Yokohama City University School of Medicine

• MATSUZAKI Michio

  Division of Transfusion Medicine Yokohama City University School of Medicine

• MOHRI Hiroshi

  First Department of Internal Medicine

• OKUBO Takao

  First Department of Internal Medicine

Bibliographic Information

Other Title

• Cytosine arabinoside少量療法が著効した低形成性混合型白血病

Abstract

A 54-year-old mele was admitted because of dyspnea on exercise. His peripheral blood revealed pancytopenia with severely hypoplastic bone marrow. Bone marrow aspiration showed a marked hypocellular marrow with 62.4% of blast cells. Cytochemical studies showed that peroxidase activity, α-nephtyl buthylate esterase activity and PAS reaction were negative, and that only ASD-chroloacetate esterase activity was positive. Surface marker analysis of blast cells showed positive result for CD5, 7, 33 and 34 antigens. The T-cell receptor β gene was rearranged, but the immunoglobulin H chain gene showed a germ line configuration. Terminal Deoxynucleotydyl Transferase (TdT) was positive, but cellular surface and cytoplasmic immunogobulin were not recognized. A diagnosis of hypoplastic mixed lineage leukemia was made and treated with low dose cytosine arabinoside, he resulted in complete remission. The relation between hypoplastic leukemia, AML-M0 and mixed lineage leukemia was also dicsussed.

Journal

• Rinsho Ketsueki

  Rinsho Ketsueki 37 (3), 233-238, 1996

  The Japanese Society of Hematology

Keywords

• hypoplastic leukemia
• mixed lineage leukemia
• low dose cytosine arabinoside therapy

Details

• CRID: 1390001205027807616
• NII Article ID: 130004500242
• NII Article ID: 10008039068
• NII Book ID: AN00252940
• DOI: 10.11406/rinketsu.37.233
• COI: 1:STN:280:DyaK283ps12gtg%3D%3D
• ISSN: 18820824
• ISSN: 04851439
• PubMed: 8727348
• Web Site: https://search.jamas.or.jp/link/ui/1996186659
• Text Lang: ja
• Data Source:
  • JaLC
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed