Effects of Reproduction on Spontaneous Development of Endometrial Adenocarcinomas and Mammary Tumors in Donryu Rats

• Takaharu Nagaoka

• Kiyoshi Takegawa

• Masaki Takeuchi

• Akihiko Maekawa

抄録

Effects of reproduction on spontaneous development of uterine endometrial adenocarcinomas and mammary tumors in Donryu rats were investigated. While the incidence of endometrial adenocarcinomas in Donryu rats was not influenced by a single reproductive experience (SRE), it showed a tendency to decrease in animals having three reproductive experiences (TRE), compared to the nulliparous case (NRE). In addition, both SRE and TRE animals showed delayed occurrence and decreased incidences and mean numbers of mammary tumors, along with reduced incidences of proliferative lesions in the pituitary gland and mucinous epithelium in the vagina. The appearancetime and incidences of persistent estrus in TRE rats were delayed and low, respectively, compared to the SRE and NRE values. The hormonal environment was altered in both groups, the prolactin level in TRE especially being decreased. These results suggest that suppression of the occurrence of endometrial adenocarcinomas and mammary tumors in rats experiencing reproduction is associated with change in the hormonal milieu.

収録刊行物

• Japanese Journal of Cancer Research

  Japanese Journal of Cancer Research 91 (4), 375-382, 2000-04

  Wiley

キーワード

• Cancer Research
• Oncology

詳細情報

• CRID: 1363951796088262912
• NII論文ID: 10008056521
• NII書誌ID: AA00690844
• DOI: 10.1111/j.1349-7006.2000.tb00955.x
• ISSN: 09105050
• ISSN: http://id.crossref.org/issn/09105050
• Web Site: https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1349-7006.2000.tb00955.x
• Web Site: https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1349-7006.2000.tb00955.x
• Web Site: https://search.jamas.or.jp/link/ui/2000196421
• データソース種別:
  • Crossref
  • CiNii Articles