Effect of Age on the Relationship between Gastric Cancer and <i>Helicobacter pylori</i>

DOI Web Site Web Site 被引用文献20件 参考文献31件

この論文をさがす

抄録

<jats:p><jats:italic>Helicobacter pylori</jats:italic> is thought to be involved in the pathogenesis of gastric cancer, but the time point at which it produces its effects (critical time) is unknown. We measured the serum level of <jats:italic>H. pylori</jats:italic> antibody in 787 gastric cancer patients and 1007 controls aged 20 to 69. Odds ratios for different gastric cancer types and stages were determined for each 10‐year age class. The overall odds ratio for gastric cancer decreased with age, being 7.0 for those aged 20–29, 14.5 for those aged 30–39, 9.1 for those aged 40–49, 3.5 for those aged 50–59, and 1.5 for those aged 60–69 (trend in odds ratios: <jats:italic>P</jats:italic> < 0.01). However, there was no such age‐dependent trend for early diffuse‐type cancer; the odds ratios were 12.6, 4.0, 7.2, 6.5, and 18.5 respectively (<jats:italic>P</jats:italic>=0.29). Early cancer tended to show higher seroprevalence than advanced cancer, especially in older subjects. No significant difference in seroprevalence was observed between diffuse and intestinal cancers within each age‐class. Seroreversion must have occurred in the time interval between the critical time and the diagnosis of the cancer, especially in older patients. The age‐dependent relationship between <jats:italic>H. pylori</jats:italic> and gastric cancer may be due to seroreversion, which itself may be independent of age. This age‐independence indicates that prolonged exposure to <jats:italic>H. pylori</jats:italic> does not increase the magnitude of its influence on gastric carcinogenesis. Possible mechanisms through which <jats:italic>H. pylori</jats:italic> exerts pathogenic effects are continuous inflammation in adulthood and/or irreversible damage to gastric mucosa in childhood or the teenage years.</jats:p>

収録刊行物

被引用文献 (20)*注記

もっと見る

参考文献 (31)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ