Expression of Human Telomerase RNA Is an Early Event of Stomach Carcinogenesis

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<jats:p>Expression of human telomerase RNA (hTR) and telomerase activity in gastric cancer and corresponding non‐cancerous mucosa were studied. Telomerase activity was detected in 23 (88%) of 26 carcinoma tissues. Although all tumor specimens and non‐cancerous mucosa expressed various levels of hTR, 21 (81%) of 26 cases expressed hTR at a higher level in the tumor than that in the corresponding mucosa. All 8 gastric carcinoma cell lines also expressed hTR at high levels. Nine (35%) of 26 non‐cancerous mucosa showed telomerase activity and all of them contained intestinal metaplasia. The incidence of telomerase‐positive mucosa in grade 2 intestinal metaplasia was significantly higher than that in grade 0 or grade 1 intestinal metaplasia, whereas hTR overexpression was found in grade 0 or grade 1 intestinal metaplasia as well as grade 2 intestinal metaplasia. The degree of <jats:italic>Heticobacter pylori</jats:italic> infection increased in parallel with the level of hTR expression and telomerase positivity. These results overall suggest that <jats:italic>Helicobacter pylori</jats:italic> infection may he a strong trigger for hTR overexpression in intestinal metaplasia, and this may lead to telomerase reactivation.</jats:p>

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