スギ花粉症に対する1年間の免疫療法 : 末梢血単核球の抗原反応性の変化 Effect of a Single Year of Allergen-Specific Immunotherapy for Seasonal Allergic Rhinitis Caused by Japanese Cedar Pollens : Changes in Response of Peripheral Blood Mononuclear Cells to Cry j 1

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This study was designed to investigate the effect of a single year of immunotherapy on cytokine synthesis by allergen-stimulated peripheral blood mononuclear cells (PBMCs) of patients with seasonal allergic rhinitis. This study included 12 nonatopic subjects (nonatopic group) and 28 patients with seasonal allergic rhinitis due to Japanese cedar pollen. Immediately after the pollen season 1998, 14 patients started receiving immunotherapy (immunotherapy group), and the remaining were treated with antihistamines during the pollen season 1999 (medication group). PBMCs (1.0×10<sup>6</sup> cells/mL) were obtained from each subject before and during the pollen season 1999, and cultured for 96 hours in the absence of and in the presence of 10μg/mL of Cry j 1. The levels of IL-4, IL-5 and IFN-γ in the supernatants were determined using enzyme-linked immunosorbent assay (ELISA). Seasonal increase in Cry j 1-specific IL-4 and IL-5 synthesis was significant in the medication group and in the immunotherapy group, but not in the nonatopic group. Although the levels of Cry j 1-dependent IL-4 and IL-5 before the pollen season did not differ significantly between the untreated group and the immunotherapy group, the levels of Cry j 1-dependent IL-4 and IL-5 during the pollen season were significantly lower in the immunotherapy group than in the untreated group. The levels of Cry j 1-dependent IL-4 before as well as during the pollen season did not differed significantly between the good and poor responders to immunotherapy, whereas the levels of Cry j 1-dependent IL-5 during the pollen season were significantly lower in the good responders than in the poor responders to immunotherapy. Therefore, we concluded that the suppression of Cry j 1-dependent IL-5-producing Th2 cells during the pollen season is a major working mechanism of a single year of immunotherapy for seasonal allergic rhinitis due to Japanese cedar pollen.

収録刊行物

  • 耳鼻咽喉科臨床

    耳鼻咽喉科臨床 94(1), 83-95, 2001-01-01

    The Society of Practical Otolaryngology

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各種コード

  • NII論文ID(NAID)
    10008095716
  • NII書誌ID(NCID)
    AN00107089
  • 本文言語コード
    JPN
  • 資料種別
    ART
  • ISSN
    00326313
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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