ヘルペスウイルス再活性化と顔面神経麻ひ　　実験的研究

DOI 被引用文献1件 参考文献18件

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  • Facial Nerve Paralysis Induced by Reactivation of Herpes Simplex Virus Type-1. An Experimental Study in Mouse.
  • -An Experimental Study in Mouse-
  • ―実験的研究―

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Recent clinical studies have strongly suggested that Bell's palsy is caused by the reactivation of latent herpes simplex type 1(HSV-1) infection in the geniculate ganglion. Although HSV-1 is a causative agent of the paralysis, the precise mechanism of the facial nerve paralysis is still unknown. In order to investigate the mechanism of Bell's palsy, we developed a mouse model of facial nerve paralysis induced by the reactivation of HSV-1. Eight weeks after recovery from facial nerve paralysis caused by inoculation with HSV-1, the mice were treated with an auricular skin scratch at the site of the previous inoculation, or with an intraperitoneal injection of anti-CD3 monoclonal antibody (mAb), or a combination of both procedures. No mice developed facial nerve paralysis when they were treated with either auricular scratch or mAb injection alone. In contrast, 2 out of 10 mice developed facial nerve paralysis with the combination of both procedures. With one exception, no mouse treated with either auricular scratch or mAb injection showed HSV-1 DNA in their facial nerve tissue, whereas 4 out of 6 mice receiving both treatments showed HSV-1 DNA on day 10 after treatment. Histopathological findings showed neuron degeneration in the geniculate ganglion and demyelination of the facial motor nerve in paralyzed mice. These findings suggest that a combination of stimuli, local skin irritation and general immunosuppression, are essential for successfully inducing facial nerve paralysis in mice with latent HSV infection.

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