Clinical Outcome of 19 Patients with Nasopharyngeal Cancer; A Review of Neo-Adjuvant Chemotherapy.

• SAKAMOTO Masayuki

  Tokyo Metropolitan Bokutoh Hospital

• KITHARA Nobuo

  Showa Public Hospital

• ICHIMURA Keiichi

  Jichi Medical College

• ASANUMA Satoshi

  Showa Public Hospital

• ABE Kazuya

  Tokyo Metropolitan Fuchu Hospital

Bibliographic Information

Other Title

• 上咽頭癌１０年間の治療成績

Abstract

We clinically examined 19 cases of nasopharyngeal cancer in which primary care was administered in the Department of Otolaryngology, Tokyo Metropolitan Fuchu Hospital between September 1990 and August 1999. The subjects consisted of 11 males and 8 females. Histophathological study revealed 17 cases of WHO type III tumors (14 cases were poorly differentiated squamous cell carcinoma and 3 cases were lymph-epithelioma). The accumulated 5-year survival rate by the Kaplan-Meier method was 50% in T1, 75% in T2, 0% in T4, and 36% overall. Neo-adjuvant chemotherapy was administered in 15 cases and distant metastasis appeared in 3 cases (21%) after definitive radiotherapy. The biological characteristic of WHO type TIE tumors is a tendency towards early metastasis, and we speculated that this might be the cause of the lower level of effectiveness of the neo-adjuvant chemotherapy in these cases. At present, this therapy is not effective and further improvement is required.

Journal

• Practica Oto-Rhino-Laryngologica

  Practica Oto-Rhino-Laryngologica 94 (7), 605-609, 2001

  The Society of Practical Otolaryngology

Keywords

• nasopharyngeal cancer
• neo-adjuvant chemotherapy
• distant metastasis
• 5-year survival rate
• radiotherapy

Details

• CRID: 1390282679235703168
• NII Article ID: 10008096958
• NII Book ID: AN00107089
• DOI: 10.5631/jibirin.94.605
• ISSN: 18844545
• ISSN: 00326313
• Web Site: https://search.jamas.or.jp/link/ui/2002020417
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed