Bell麻痺と単純ヘルペスウイルス Bell's Palsy and Herpes Simplex Virus

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Bell's palsy is the most common cause of facial paralysis; it has an incidence of 20 to 30 per 100, 000 people. Many events such as viral infection, is chemia and autoimmune reaction have been proposed as causes of Bell's palsy. However, to date there have been no reports of conclusive evidence of the etiological agent responsible for Bell's palsysince Sir Charles Bell described the disease in 1830. Because the etiological agent remains unknown, treatment of this condition is empiric, varying from observation alone to the use of steroids and surgical decompression.<br>Recent advancements in the molecular methods of <i>in situ</i> hybridization and polymerase chain reaction have revealed the existence of HSV-1 genomes in the involved facial nerve as well as the geniculate ganglion. In addition, animal experiments have shown that HSV-1 may induce facial paralysis and the beneficial effect of the antiviral agent of acyclovir for facial function has also been demonstrated. These findings provide the evidence that latently infected HSV-1 causes Bell's palsy when it reactivates and it is controversial whether we should continue using the term "Bell's palsy" to mean "idiopathic facial paralysis" or whether we should now recognize Bell's palsy as "herpetic facial paralysis". However, currently, we have no reliable, widely available clinical test for the early identification of HSV-1 infection in Bell's patients. Methodological break-through will resolve this problem and data accumulation will datermine the percentage of patients with Bell's palsy in whom HSV-1 is the etiological agent.

収録刊行物

  • 耳鼻咽喉科臨床

    耳鼻咽喉科臨床 94(10), 857-868, 2001-10-01

    The Society of Practical Otolaryngology

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各種コード

  • NII論文ID(NAID)
    10008097694
  • NII書誌ID(NCID)
    AN00107089
  • 本文言語コード
    JPN
  • 資料種別
    ART
  • ISSN
    00326313
  • NDL 記事登録ID
    5925798
  • NDL 雑誌分類
    ZS43(科学技術--医学--耳鼻咽喉科学)
  • NDL 請求記号
    Z19-421
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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