Nasal Antigen Challenge of Japanese Cedar Pollinosis. An on Season and off Season Comparison.

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  • スギ花粉飛散期，非飛散期の抗原鼻誘発反応　　定量的鼻誘発試験を中心に
  • -An on Season and off Season Comparison-
  • ―定量的鼻誘発試験を中心に―

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Abstract

Objective: The antigen-induced nasal mucosal reaction between the pollen and pollen-free seasons was quantitatively compared in Japanese cedar pollinosis patients.<br>Subjects: The subjects were 52 patients diagnosed with pollinosis at the outpatient clinic of the Toho University Ohashi Hospital between 1985 and 1990.<br>Methods: A cedar antigen disk was bilaterally applied to the anteromedial aspect of the inferior nasal concha, and nasal respiratory resistance was continuously measured bilaterally by rhinography for 8 minutes.<br>Results: Nasal respiratory resistance was compared between 18 positive cases during the pollination season and 10 positives cases during the pollen-free season. There was a significant difference between the seasons with respect to the frequency of the nasal mucosal reaction alone as assessed by t-test, but there was no significant difference between the seasons in initial nasal respiratory resistance or nasal mucosal sensitivity. Nasal respiratory resistance was significantly higher in the patients sneezing during the nasal mucosal reaction than in the patients who gave a positive reaction to the provocation test, as assessed by t-test.<br>Conclusion: The results showed that the nasal mucosal sensitivity of pollinosis patients is elevated resulting in aggravated nasal obstruction by antigen challenge. Thus, pollinosis patients who sneeze easily and have nasal mucosal hypersensitivity to antigen challenge may be prone to nasal obstruction.

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