プランルカストと抗ヒスタミン薬の併用効果

DOI 被引用文献2件 参考文献24件

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  • Pranlukast Produces Beneficial Effects in Nasal Symptoms on Patients with Perennial Allergic Rhinitis when Used in Combination with an Antihistamine.

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We investigated the effects of the combination therapy of leukotriene receptor antagonist (Pranlukast) and an antihistamine (Clemastine Fumarate) on patients with perennial allergic rhinitis. There was no significant difference between the combination (Pranlukast and Clemastine Fumarate) group (n=14) and the single (only Pranlukast) group (n=14) in terms of global improvement rating. In regard to improvements in the three major symptoms of allergic rhinitis, suppression of sneezing and rhinorrea were significantly better in the combination group in comparison with the single group at assessments one and two weeks after the start of administration (p<0.05). However, there was no significant difference between the two groups in regard to congestion. Moreover, in regard to intra nasal findings, the mean score of the nasal secretion of rhinoscopic findings was significantly decreased after administration in the combination group, but there was no significant change in the score in the single group (p<0.05).<br>These findings suggest that Pranlukast, in combination with an antihistamine, produces beneficial effects on sneezing and rhinorrea in patients with perennial allergic rhinitis.

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