通年性アレルギー性鼻炎に対する免疫療法 : T細胞の抗原反応性からみた作用機序 Allergen-Specific Immunotherapy for Perennial Allergic Rhinitis : Changes in Allergen-Specific T Cell Responses

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This study was designed to investigate the working mechanism of Immunotherapy at the level of T cell reactivity to the allergen and to determine possible predictable factors of successful Immunotherapy for allergic rhinitis. Peripheral blood mononuclear cells were obtained from 60 patients with perennial allergic rhinitis due to Dermatophagoides farinae, and were cultured with Der f 1 for 96 hours to determine the cytokine synthesis. Forty-six patients were treated for 2 years with Immunotherapy using standardized D. farinae extracts, and the remainder were treated with antiallergic medications. Clinical improvement was obtained in more than 90% of the patients treated with Immunotherapy. IL-5 synthesis was significantly reduced in the patients treated with Immunotherapy. However, such reduction was not observed in the patients treated with antiallergic medications. The suppression of the allergen-induced IL-5 synthesis was most likely to be involved in the working mechanism of Immunotherapy. However, this study has failed to determine predictable factors of successful Immunotherapy for allergic rhinitis.

収録刊行物

  • 耳鼻咽喉科臨床

    耳鼻咽喉科臨床 95(1), 93-104, 2002-01-01

    The Society of Practical Otolaryngology

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各種コード

  • NII論文ID(NAID)
    10008098751
  • NII書誌ID(NCID)
    AN00107089
  • 本文言語コード
    JPN
  • 資料種別
    ART
  • ISSN
    00326313
  • データ提供元
    CJP書誌  J-STAGE 
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