耳鼻咽喉科処置 : 鼻咽腔処置の有用性 The Efficacy of Nasopharyngeal Topical Treatment

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著者

    • 伊藤 真人 ITO Makoto
    • 金沢大学大学院医学系研究科脳医科学専攻脳病態医学講座・感覚運動病態学 Kanazawa University
    • 白井 明子 SHIRAI Akiko
    • 金沢大学大学院医学系研究科脳医科学専攻脳病態医学講座・感覚運動病態学 Kanazawa University
    • 三輪 高喜 MIWA Takaki
    • 金沢大学大学院医学系研究科脳医科学専攻脳病態医学講座・感覚運動病態学 Kanazawa University
    • 古川 仭 FURUKAWA Mitsuru
    • 金沢大学大学院医学系研究科脳医科学専攻脳病態医学講座・感覚運動病態学 Kanazawa University

抄録

Recently, a rapid increase in penicillin resistant pneumococci has been reported in most areas of the world. These penicillin resistant bacteria are becoming less susceptible to other commonly prescribed oral antimicrobial drugs, including extended-spectrum cephalosporins. Also, a rapid spread of ampicillin resistant Haemophilus influenzae in children with respiratory tract infections has been reported in Japan. Therefore, we carried out clinical and bacteriological studies of topical treatment of the nasopharynx in patients with pediatric acute otitis media at 3 general hospitals and 6 clinics.<br>Between February and May 2000, 30 strains of Streptococcus pneumoniae and 19 strains of Haemophilus influenzae were isolated from the nasopharynx in 42 children with acute otitis media. Of the 30 Streptococcus pneumoniae, penicillin G resistant S. pneumoniae (PRSP) and penicillin G intermediately resistant S. pneumoniae (PISP) accounted for 55% and 10% of the total, respectively. On the other hand, 26% of the 19 Haemophilus influenzae were β-lactamase-negative ampicillin-resistant (BLNAR) strains.<br>The bacteriological efficacy of topical treatment of the nasopharynx combined with appropriate oral antimicrobial drugs in patients with PRSP, PISP and BLNAR was 57%, 50% and 60%, respectively. On the other hand, the bacteriological efficacy of only oral antimicrobial drugs in patients with PRSP, PISP and BLNAR was 20%, 43% and 63% respectvely. These results suggest that the success rate of the sterilization of pediatric nasopharynxes using a topical treatment combined with oral antimicrobial drugs is higher than treatments using only oral antimicrobial drugs.

収録刊行物

  • 耳鼻咽喉科臨床

    耳鼻咽喉科臨床 95(2), 145-151, 2002-02-01

    The Society of Practical Otolaryngology

参考文献:  12件中 1-12件 を表示

被引用文献:  5件中 1-5件 を表示

各種コード

  • NII論文ID(NAID)
    10008098936
  • NII書誌ID(NCID)
    AN00107089
  • 本文言語コード
    JPN
  • 資料種別
    NOT
  • ISSN
    00326313
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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