Blood Gas Changes in Duchenne Type Muscular Dystrophy.

DOI 2 Citations 9 References

Bibliographic Information

Other Title
  • Ｄｕｃｈｅｎｎｅ型筋ジストロフィー症における動脈血液ガス分析値の経年変化

Search this article

Abstract

We studied changes in blood gas data from 32 patients with Duchenne type muscular dystrophy (DMD), who were followed for more than 5 years. Regression lines for each blood gas variable were obtained by the least square regression method, from 276 observations. The mean change per year was calculated by averaging the individual slolpes.<br>All blood gas variables (PaO<sub>2</sub>, PaCO<sub>2</sub>, pH, and [HCO3-]) correlated significantly with age the regression lines were:<br>PaO<sub>2</sub>=95.6-0.45×Age, PaCO<sub>2</sub>=34.7+0.70×Age, pH=7.397-0.0023× Age, [HCO3-]=20.7+0.28×Age.<br>The rates of change were-0.74 Torr/year for PaO<sub>2</sub>, 1.07 Torr/year for PaCO<sub>2</sub>, -0.0028 per year for pH and 0.55mEq/l/year for [HCO3-]. The slope of each regression line was within the average individual yearly change±one standard deviation. AaDo2 did not change significantly with age, but chronic respiratory acidosis worsened because of alveolar hypoventilation.<br>As an index of the severity of DMD, PaCO<sub>2</sub> was better than PaO<sub>2</sub>, because the former was more strongly correlated with age and the values of PaCO<sub>2</sub> deviated less from the regression line.

Journal

Citations (2)*help

See more

References(9)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top