Interferon Production in Peripheral Blood Cells of Patients with Pulmonary Mycobacterial Disease.

DOI PubMed 15 References
  • Tada Atsuhiko
    Department of Internal Medicine, National Sanatorium Minami-Okayama Hospital
  • Kawahara Shin
    Department of Internal Medicine, National Sanatorium Minami-Okayama Hospital
  • Tamaoki Akihiko
    Department of Internal Medicine, National Sanatorium Minami-Okayama Hospital
  • Okada Chiharu
    Department of Internal Medicine, National Sanatorium Minami-Okayama Hospital
  • Takeuchi Makoto
    Department of Internal Medicine, National Sanatorium Minami-Okayama Hospital
  • Tanimoto Yasushi
    Department of Internal Medicine, National Sanatorium Minami-Okayama Hospital
  • Mishima Yasuo
    Department of Internal Medicine, National Sanatorium Minami-Okayama Hospital
  • Soda Ryo
    Department of Internal Medicine, National Sanatorium Minami-Okayama Hospital
  • Takahashi Kiyoshi
    Department of Internal Medicine, National Sanatorium Minami-Okayama Hospital
  • Kibata Masayoshi
    Department of Internal Medicine, National Sanatorium Minami-Okayama Hospital

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Other Title
  • 肺抗酸菌症患者末梢血細胞のインターフェロン産生能

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Abstract

Production of interferon (IFN)-α and IFN-γ were examind in 31 patients with acute tuberculosis, 12 patients with atypical mycobacterial disease. IFN production was examined in cultures of unseparated fresh whole blood. Production of IFN-α was induced by hemagglutinating virus of Japan and production of IFN-γ was induced by PHA. Patients with mycobacterial desease produced significantly less IFN-α than healthy subjects. In patients with acute tuberculosis, effective chemotherapy for 2 months restored IFN-α production. Patients produced less IFN-γ than healthy subjects, but the difference was not significant. Patients with high serum CRP levels tended to produce little IFN-α. These results suggest that measurement of IFN production is useful for immunological evaluation of patients with mycobacterial disease.

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