Myocardial Structural Proteins in Cor Pulmonale. Analysis by Two-Dimensional Electrophoresis.

• Minami Hiroaki

  First Department of Internal Medicine, Asahikawa Medical College

• Matsumoto Hiroyuki

  国立療養所道北病院

• Nagane Tadato

  First Department of Internal Medicine, Asahikawa Medical College

• Takeda Akinori

  First Department of Internal Medicine, Asahikawa Medical College

• Yahara Osamu

  First Department of Internal Medicine, Asahikawa Medical College

• Nakano Hitoshi

  First Department of Internal Medicine, Asahikawa Medical College

• Yamazaki Yasuhiro

  First Department of Internal Medicine, Asahikawa Medical College

• Osanai Shinobu

  First Department of Internal Medicine, Asahikawa Medical College

• Akiba Yuji

  First Department of Internal Medicine, Asahikawa Medical College

• Kikuchi Kenjiro

  First Department of Internal Medicine, Asahikawa Medical College

Bibliographic Information

Other Title

• 肺性心における心筋構造タンパク質の変化　二次元電気泳動法を用いての検討
• Analysis by Two-Dimensional Electrophoresis
• 二次元電気泳動法を用いての検討

Abstract

Changes in cardiac structural proteins caused by cor pulmonale were studied with two-dimensional electrophoresis. Sprague-Dawley rats were exposed to an oxygen-poor gas mixture (10%O₂/90%N₂) for three weeks. These rats (the hypoxic group) were compared to a control group that was kept in room air. Hemoglobin, hematocrit, and right ventricular systolic pressure were greater in the hypoxic group than in the control group. After the third week, desmin content of both ventricular muscles had increased in the hypoxic group, and was significantly greater in the hypoxic group than in the control group. The contents of other cardiac structural proteins did not change. These data suggest that increases in desmin are caused by adaptation of the myocardium to pressure overload associated with pulmonary hypertension. However, increases in the desmin content of the left ventricular muscle might be caused by volume overload, humoral factors, or might be a direct effect of hypoxemia.

Journal

• The Japanese journal of thoracic diseases

  The Japanese journal of thoracic diseases 33 (6), 599-604, 1995

  The Japanese Respiratory Society

Keywords

• Cor pulmonale
• Hypoxia
• Structural protein
• Two-dimensional electrophoresis
• Desmin

Details

• CRID: 1390001205018754176
• NII Article ID: 130003678815
• NII Article ID: 10008107401
• NII Book ID: AN00187758
• DOI: 10.11389/jjrs1963.33.599
• ISSN: 1883471X
• ISSN: 03011542
• PubMed: 7666613
• Web Site: https://search.jamas.or.jp/link/ui/1996058095
• Text Lang: ja
• Data Source:
  • JaLC
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed