モルモットの高張食塩水誘発気管支収縮（ＨＳＩＢ）の機序の検討

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  • Mechanisms of Hypertonic Saline-induced Bronchoconstriction in Guinea Pigs.

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We examined whether inhalation of hypertonic saline can induce bronchoconstriction in guinea pigs, and also studied the mechanisms of this bronchoconstriction. Twenty-five male Hartley guinea pigs were divided into the following 5 groups: G-1, 0.9% saline inhalation; G-2, non-treatment and inhalation of hypertonic saline; G-3, capsaicin pretreatment and inhalation of hypertonic salines; G-4, ipratropium bromide pretreatment and inhalation of hypertonic saline; G-5, chlorpheniramine pretreatment and inhalation of hypertonic saline.<br>RL and Cdyn were serially measured to assess bronchoconstriction, and the percent increase in RL from the the value measured before inhalation of hypertonic saline (%RL) was analyzed. The maximum %RL was 9.2±3.8% in G-1, 90.6±6.6% in G-2, 11.2±5.7% in G-3, 9.0±6.0% in G-4, and 47.8±4.0% in G-5. The values in G-3 and G-4 were significantly lower than in G-2. We conclude that inhalation of hypertonic saline causes concentration dependent bronchoconstriction in guinea pigs and that both non-adrenergic non-cholinergic nerves and cholinergic nerves may play an important role in this bronchoconstriction.

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