Effect of Cytokine RANTES on Induction of Activated Eosinophils.

• Kakazu Tomokazu

  First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus

• Chihara Junichi

  Department of clinical and Laboratory Medicine, Akita University school of Medicine

• Saito Atsushi

  First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus

• Nakajima Shigenori

  Fourth Department of Internal Medicine, Kinki University School of Medicine

Bibliographic Information

Other Title

• ＲＡＮＴＥＳの活性化好酸球への誘導作用

Abstract

The cytokine RANTES (regulated on activation, normal T expressed and secreted) is a member of the platelet factor 4 superfamily and is a chemoattractant for eosinophils. To study the effect of RANTES on induction of activated eosinophils, flow cytometry was used to measure the expression of intracellular EG2 in eosinophils. The concentration of eosinophil cationic protein in the culture supernatant of eosinophils stimulated with RANTES was also measured.<br>Expression of EG2 and the mean fluorescence intensity ratio were greater in eosinophils stimulated with RANTES than in control eosinophils. Eosinophils stimulated with RANTES also produced more eosinophil cationic protein than did control eosinophils.

Journal

• The Japanese journal of thoracic diseases

  The Japanese journal of thoracic diseases 33 (11), 1226-1232, 1995

  The Japanese Respiratory Society

Keywords

• Degranulation
• Intracellular immunofluorescent stain
• normal T expressed and secreted (RANTES)
• Activated Eosinophils
• Regulated on activation

Details

• CRID: 1390282679994192896
• NII Article ID: 130003678711
• NII Article ID: 10008108733
• NII Book ID: AN00187758
• DOI: 10.11389/jjrs1963.33.1226
• ISSN: 1883471X
• ISSN: 03011542
• PubMed: 8583714
• Web Site: https://search.jamas.or.jp/link/ui/1996150584
• Text Lang: ja
• Data Source:
  • JaLC
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed