歯肉転移で発見されたＧ‐ＣＳＦ産生肺大細胞癌の１例

DOI PubMed 被引用文献5件 参考文献13件

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  • Gingival Metastasis of Large-cell Lung Cancer that Produced G-CSF.

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A 68-year-old man was referred to our hospital for further examination of a gingival mass. Chest radiographs and magnetic resonance imaging disclosed a bulky mass originating in the upper portion of the left lung, in contact with a chronic empyema lesion that first occurred after resection for pulmonary tuberculosis. Examination of a specimen obtained by percutaneous needle biopsy of the mass led to the diagnosis of large-cell carcinoma. Laboratory findings on admission showed marked leukocytosis (48, 100/μl) without evidence of severe a bacterial infection. The level of G-CSF in serum was abnormally high (246pg/ml, normal value: <30pg/ml). Chemotherapy with vindesine, ifosfamide, and cisplatin resulted in shrinkage of the gingival mass, and a decrease in the G-CSF level to 66pg/ml.<br>Immunohistochemical staining with an anti-G-CSF monoclonal antibody to the primary lung tumor and the gingival mass obtained at autopsy was positive for cytoplasmic G-CSF.

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