Effects of Subacute Hypoxia on Alveolar Epithelial Ion Transport in Rats.

DOI PubMed 3 Citations 20 References
  • Suzuki Satoshi
    Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University
  • Hoshikawa Yasushi
    Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University
  • Ouo Sadafumi
    Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University
  • Sakuma Tsutomu
    Department of Surgery, Sendai Kosei Hospital
  • Koike Kaoru
    Respiratory Division, Miyagi Cancer Center
  • Tanita Tatsuo
    Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University
  • Fujimura Shigefumi
    Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University

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  • 低酸素曝露が肺胞上皮のイオントランスポートに及ぼす影響

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Abstract

To study the effects of subacute hypoxia on alveolar epithelial ion transport, alveolar fluid clearance was measured in isolated fluid-filled rat lungs. After instillation of a solution containing about 5% bovine albumin, an increase in alveolar fluid clearance was measured over 2 hours. Alveolar fluid clearance was lower when rats were kept in hypoxic conditions (FiO2=0.1) for 48 hours. Neither 10-5M amiloride (a Na+-channel blocker) nor 10-3 M ouabain (an inhibitor of Na+-K+-ATPase) inhibited fluid clearance in the hypoxia group, but they did in the normoxia group. These results indicate that subacute hypoxia may down-regulate both the Na+-channl and Na+-K+-ATPase, and thus decrease the absorption of excess alveolar fluid.

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