A High Concentration of Itraconazole in an Aspergilloma.

DOI PubMed 2 Citations 11 References
  • Niwa Hiroshi
    Second Department of Surgery, Nagoya City University, Medical School
  • Yamakawa Yosuke
    Second Department of Surgery, Nagoya City University, Medical School
  • Kondo Kaoru
    Second Department of Surgery, Nagoya City University, Medical School
  • Kiriyama Masanobu
    Second Department of Surgery, Nagoya City University, Medical School
  • Kondo Satoshi
    Second Department of Surgery, Nagoya City University, Medical School
  • Kani Hisanori
    Second Department of Surgery, Nagoya City University, Medical School
  • Masaoka Akira
    Second Department of Surgery, Nagoya City University, Medical School

Bibliographic Information

Other Title
  • 菌球中でｉｔｒａｃｏｎａｚｏｌｅが高濃度を示した肺アスペルギルス症の１例

Search this article

Abstract

A 66-year-old woman was given 100mg/day of itraconazole for eight months to treat pulmonary aspergillosis with an aspergilloma. The amount of purulent sputum decreased, but open drainage was done because the fever continued and because no improvement was seen on the chest X-ray film. No aspergillus was cultured from the surgical specimen, but fungi were observed microscopically.<br>The concentration of itraconazole in plasma was 249ng/ml. The concentrations in specimens of the lung and of the aspergilloma obtained by thoracotomy were 81ng/g and 837ng/g, respectively. The high concentration in the aspergilloma had made the fungus inactive. The itraconazole concentration may have been very high for three reasons: (1) the concentration increased in purulent fluid, (2) itraconazole easily entered the aspergilloma through the root at the cavity wall, and (3) itraconazole dissolved in lipid derived from destroyed fungus.

Journal

Citations (2)*help

See more

References(11)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top