Invasive Pulmonary Aspergillosis in a Patient with Acute Leukemia. The Role of Neutrophil Elastase in in Cavity Formation.

• Oe Hidemi

  First Department of Internal Medicine, Kagawa Medical School

• Fujita Jiro

  First Department of Internal Medicine, Kagawa Medical School

• Ohnishi Hiroaki

  First Department of Internal Medicine, Kagawa Medical School

• Yamaji Yasufumi

  First Department of Internal Medicine, Kagawa Medical School

• Takahara Jiro

  First Department of Internal Medicine, Kagawa Medical School

Bibliographic Information

Other Title

• 急性骨髄性白血病患者に合併した侵襲型肺アスペルギルス症の１例
• The Role of Neutrophil Elastase in in Cavity Formation

Abstract

A 47-year-old man complaining of common cold-like symptoms was admitted to our hospital. Acute myelogenous leukemia was diagnosed and the patient was treated with induction chemotheapy. During granulocytopenia caused by induction chemotherapy, a nodular lesion appeared in the right upper lobe. The nodular lesion changed to a cavitary lesion after the recovery of peripheral white blood cell counts. A transbronchial biopsy specimen obtained from the right B³b showed Aspergillus. Oral itraconozole, flucytosine, and itravenous amphotericin B were given. The cavitary lesion in the right upper lobe regressed after anti-fungal therapy was started. During granulocytopenia caused by consolidation chemotherapy, the nodular lesion enlarged again. Thereafter, as bone marrow recovered, it changed to a cavitary lesion with a lung ball inside. In both episodes, a nudular lesion appeared during granulocytopenia, and changed to a cavitary lesion after bone marrow recovery. In addition, the level of neutrophil elastase reached its maximum at the time of the bone marrow recovery. These findings suggest that white blood cells of the host as well as neutrophil elastase play an important role in cavitation in pulmonary aspergillosis.

Journal

• The Japanese journal of thoracic diseases

  The Japanese journal of thoracic diseases 34 (4), 459-464, 1996

  The Japanese Respiratory Society

Keywords

• Invasive pulmonary aspergillosis
• Acute myelogeneous leukemia
• Cavity formation
• Neutrophil elastase

Details

• CRID: 1390001205017394944
• NII Article ID: 130003679258
• NII Article ID: 10008109577
• NII Book ID: AN00187758
• DOI: 10.11389/jjrs1963.34.459
• COI: 1:STN:280:DyaK283mtFWrsA%3D%3D
• ISSN: 1883471X
• ISSN: 03011542
• PubMed: 8691669
• Web Site: https://search.jamas.or.jp/link/ui/1997017290
• Text Lang: ja
• Data Source:
  • JaLC
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed