間質性肺炎のマーカーＫＬ‐６の有用性の検討

• 濱田 泰伸

  国立療養所近畿中央病院内科

• 坂谷 光則

  国立療養所近畿中央病院内科

• 上田 英之助

  国立療養所近畿中央病院内科

書誌事項

タイトル別名

• KL-6 in Patients with Interstitial Pneumonitis.

抄録

Levels of KL-6 are high in serum and in bronchoalveolar lavage fluid (BALF) from patients with interstitial pneumonitis. To examine the usefulness of the KL-6 level as a marker of disease activity in interstitial pneumonitis, KL-6 was measured in serum and in BALF from patients with this disease. Correlation between KL-6 levels and the number of cells in BALF and between KL-6 levels and pulmonary function were computed. Serum KL-6 levels were abnormally high and correlated with the number of lymphocytes in BALF in patients with interstitial pneumonitis. Furthermore, changes in serum KL-6 levels reflected clinical courses in these patients. KL-6 levels in BALF were very high and correlated with the total number of cells, and with the numbers of lymphocytes, neutrophils, and eosinophils in BALF. KL-6 levels in serum and in BALF correlated significantly with %VC, %DL_CO, and %DL_CO/VA. These results suggest that KL-6 levels in serum and in BALF reflect the degree of alveolitis and of deterioration of pulmonary function in these patients, and that KL-6 is a useful indicator of disease activity in interstitial pneumonitis.

収録刊行物

• 日本胸部疾患学会雑誌

  日本胸部疾患学会雑誌 34 (7), 771-777, 1996

  社団法人 日本呼吸器学会

キーワード

• 間質性肺炎
• KL-6
• 血清マーカー
• 気管支肺胞洗浄液
• 呼吸機能検査

詳細情報

• CRID: 1390282679992978816
• NII論文ID: 130003679315
• NII論文ID: 10007009308
• NII論文ID: 10008110413
• NII書誌ID: AN00187758
• DOI: 10.11389/jjrs1963.34.771
• ISSN: 1883471X
• ISSN: 03011542
• PubMed: 8810758
• Web Site: https://search.jamas.or.jp/link/ui/1997037930
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可