肺扁平上皮癌は肺内で肺胞基底膜と肺胞上皮間で発育する Growth of Squamous Cell lung Cancer between Alveolar Basement Membrane and Alveolar Epithelium

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肺扁平上皮癌が肺実質では肺胞基底膜と肺胞上皮間に発育するとの報告を確認することを目的に免疫組織化学的手法を使用して検索を行った. 対象は肺実質で発育している扁平上皮癌41病変(男36, 女5例, 平均年齢65歳) である. 小細胞癌8病変 (男6例, 女2例, 平均年齢64歳), 腺癌71病変 (男48, 女23例, 平均年齢62歳) を対照とした. パラフィン包埋した腫瘍組織切片を対象に各種の染色を行った. 扁平上皮癌では, 細胞異型のない, p53染色陰性の2型肺胞上皮からなる腺管様構造 (非異型腺管) が90%の頻度で見いだされた. 扁平上皮癌の分化度や腫瘍発生部位での差はなかった. 一方小細胞癌では25%の陽性で, 腫瘍のごく一部にのみ見られ, 腺癌ではそれはみられなかった. 肺胞基底膜と肺胞上皮間での発育は扁平上皮癌に特徴的な発育様式であることが確認された.

We examined patterns of growth of cancer cells in specimens of alveoli taken from 41 patients with squamous cell carcinoma (36 men and 5 women, mean age of 65 years). For comparison, 8 samples from patients with small cell carcinoma (6 men and 2 women, mean age 64) and 71 samples from patients with adenocarcinoma (48 men and 23 women, mean age 62) were also studied. The samples were fixed in formalin, embedded in paraffin, and then subjected to immunostaining. Gladular structures composed of non-atypical cuboidal cells with negative p53 staining and scanty positive PCNA staining were found in 90% of the samples of squamous cell carcinoma.<br>In small cell carcinoma, 25% of the samples had small numbers of non-atypical glandular structures. In adenocarcinoma, no non-atypical glandular structures were seen. Glandular structures were observed in the periphery of the cancerous tissue. Some of these non-atypical cells were attached to the alveolar basement membranes. We conclude that squamous cell carcinoma grows between the basement membrane and the alveolar epithelium, and leaves noncancerous epithelium with glandular structure.

収録刊行物

  • 日本胸部疾患学会雑誌 = The Japanese journal of thoracic diseases

    日本胸部疾患学会雑誌 = The Japanese journal of thoracic diseases 34(8), 878-884, 1996-08-25

    The Japanese Respiratory Society

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各種コード

  • NII論文ID(NAID)
    10008110704
  • NII書誌ID(NCID)
    AN00187758
  • 本文言語コード
    JPN
  • 資料種別
    ART
  • ISSN
    03011542
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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