Two Cases of Pulmonary Disease Caused by Mycobacterium chelonae subsp. abscessus.
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- Naoki Katsuhiko
- National Higashi-saitama Hospital
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- Oosumi Mitsuhiko
- National Higashi-saitama Hospital
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- Takasugi Tomoaki
- National Higashi-saitama Hospital
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- Toyoda Takeo
- National Higashi-saitama Hospital
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- Kawashiro Takeo
- National Higashi-saitama Hospital
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- Aoyagi Teruo
- National Higashi-saitama Hospital
Bibliographic Information
- Other Title
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- Mycobacterium chelonae subsp. abscessusによる肺感染症2例
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Abstract
We encountered two cases of pulmonary disease caused by M. chelonae subsp. abscessus.<br>[Case 1] A 72-year-old man was admitted to the hospital because of fever. He had been observed for one year after being given a diagnosis of pulmonary disease caused by Myocobacterium avium complex. Sputum examination revealed acid-fast bacilli (Gaffky 9). He recovered after administration of clarithromycin (CAM) and other drugs.<br>[Case 2] A 61-year-old man was admitted to the hospital because of coughing and sputum production. He had been observed for 4 years after being given a diagnosis of pulmonary M. fortuitum disease. Sputum examination revealed acid-fast bacilli (Gaffky 7). His symptoms deteriorated even though he received anti-tuberculosis agents and CAM. After measurement of minimal inhibitory concentration (MIC), he was given amikacin (AMK).<br>In both cases, the bacilli found in sputum obtained on admission were identified as M. chelonae subsp. abscessus by DNA hybridization. They were completely resistant to all anti-tuberculosis agents. However, the disk method show that they were sensitive to AMK, imipenem and CAM. The MIC value of those strains to CAM was 0.78μg/ml in case 1 and more than 100μg/ml in case 2. The results obtained by MIC measurement were consistent with the clinical outcome. AMK, cefoxitin (CFX), and CAM had been used to treat M. chelonae subsp. abscessus in Europe, but the MIC value differed from strain to strain within a species. Thus the present data suggest that measurement of the MIC value of CAM would be necessary to predict its therapeutic effect.
Journal
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- The Japanese journal of thoracic diseases
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The Japanese journal of thoracic diseases 34 (11), 1264-1270, 1996
The Japanese Respiratory Society
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Details 詳細情報について
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- CRID
- 1390282679995317504
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- NII Article ID
- 130003678927
- 10008111629
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- NII Book ID
- AN00187758
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- COI
- 1:STN:280:DyaK2s7jtVaqtA%3D%3D
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- ISSN
- 1883471X
- 03011542
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- PubMed
- 8976085
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- Text Lang
- ja
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- Data Source
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- JaLC
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed