Pulmonary Infiltration with Eosinophilia due to Rabbit-fur Antigen: Diagnosis by Allergen Inhalation Test.

  • Hommura Fumihiro
    First Department of Medicine, School of Medicine, Hokkaido University
  • Munakata Mitsuru
    First Department of Medicine, School of Medicine, Hokkaido University
  • Doi Isamu
    First Department of Medicine, School of Medicine, Hokkaido University
  • Nasuhara Yasuyuki
    First Department of Medicine, School of Medicine, Hokkaido University
  • Kawakami Yoshikazu
    First Department of Medicine, School of Medicine, Hokkaido University

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Other Title
  • 吸入誘発で診断したウサギ毛抗原によるPIE症候群の1例

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Abstract

We report the case of a 48-year-old man with asthma and pulmonary eosinophilia. He presented with coughing, dyspnea, and wheezing that began 6 months after he began keeping a rabbit in his house. He was referred to our department for further examination of pulmonary infiltrative shadows. An inhalation test with rabbit-fur antigen induced both immediate and late asthmatic responses. In addition, infiltrative shadows appeared in the right segments 2, 8, and 9 on chest CT films after the antigen inhalation. Examination of fluid obtained by bronchoalveolar lavage from the right S9 showed an increase in the fraction of eosinophils. Examination of a specimen obtained by transbronchial lung biopsy from those segments revealed infiltration of inflammatory cells into the alveolar septa and alveolar spaces, which was consistent with eosinophilic pneumonia. Our diagnosis was asthma and pulmonary eosinophilia due to rabbit-fur antigen.

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