当院における多剤耐性結核症例の臨床的検討 CLINICAL ANALYSIS OF MULTIDRUG-RESISTANT TUBERCULOSIS

この論文にアクセスする

この論文をさがす

著者

抄録

Forty-three patients with multidrug-resistant tuberculosis at National Chiba-Higashi Hospital were studied retrospectively. TB cases excreting tubercle bacilli which are resistant to both 0.1 μg/ml of isoniazid and 50 μg/ml of rifampicin were defined as multidrug-resistant cases. From 1993 to 1997, we experienced 1627 patients with pulmonary tuberculosis, and among them 43 patients (23-79 years old, 35 males and 8 females)were proved to be multidrug-resistant. Six cases were initially treated cases and other 37cases had been treated previously. On admission, 40 out of 43 cases (93.0 %) were smear positive by sputum examination of mycobacteria and 38 out of 43 cases (88.4 ) had cavitary lesions on chest X-ray. Six patients were complicated with diabetes mellitus, two with cancer, one with alcohol dependence, one with chronic hepatitis, and others did not have prominent complications. Three operated patients were cured, the fact shows that the surgical treatment is still a useful measure for cases with the indication. Sixteen patients were cured, eight were still under treatment, and thirteen were died of tuberculosis. One of reasons of poor prognosis of multidrug - resistant tuberculosis is that multidrug-resistant tubercle bacilli are usually resistant to other drugs, too. In case of multidrug-resistant tuberculosis, patients were obliged to be treated in a hospital longterm to prevent the spread of tubercle bacilli. Therefore, it is very important to find out new tuberculosis cases as an early as possible, treat them with proper regimen and prevent dropout by directly observed therapy, thus preventing the emergence of multidrugresistant tuberculosis. Development of new antituberculous agents is strongly expected.

収録刊行物

  • 結核

    結核 76(12), 717-721, 2001-12-15

    JAPANESE SOCIETY FOR TUBERCULOSIS

参考文献:  12件中 1-12件 を表示

被引用文献:  3件中 1-3件 を表示

各種コード

  • NII論文ID(NAID)
    10008113099
  • NII書誌ID(NCID)
    AN00073442
  • 本文言語コード
    JPN
  • 資料種別
    ART
  • ISSN
    00229776
  • NDL 記事登録ID
    026781012
  • NDL 請求記号
    Z19-133
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
ページトップへ