Rheumatoid arthritis.

• Takahashi Hiroki

  First Department of Internal Medicine, Sapporo Medical University School of Medicine

Bibliographic Information

Other Title

• 逐に開始されたモノクローナル抗体による治療　　慢性関節リウマチ
• 慢性関節リウマチ
• Rheumatoid arthritis

Abstract

Rheumatoid arthritis is a chronic inflammatory disease of joints with the potential to cause substantial joint damage and disability. Proinflammatory cytokines(TNFα, IL-6, IL-1) have recently been shown to play important roles in the pathogenesis of rheumatoid arthritis. In addition, advances in the field of genetic engineering have made possible therapies using monoclonal antibody targeting specific inflammatory mediators. Infliximab is a chimeric anti-TNFα monoclonal antibody that is already available for rheumatoid arthritis patients in the United States and European countries following the results of multiple double-blinded placebo-controlled trials. Infliximab has been demonstrated to improve symptoms and signs of synovitis, and to prevent radiographic evidence of progeressive joint damage in a majority of patients with rheumatoid arthritis. However, increased susceptibility to infection is a potential concern with agents inhibiting TNFα as the cytokine plays a central role in host defense. In fact, several kinds of infection, including tuberculosis, have been reported as adverse events following anti-TNFα blockade therapy. Physicians are therefore recommended to screen patients for latent tuberculosis infection or disease before initiating such therapies. IL-6 is likely to be involved in the pathogenesis of rheumatoid arthritis in addition to TNFα. Clinical trials into IL-6 blockade therapy using complementarity determining regions (CDR)-grafted anti-human IL-6 receptor monoclonal antibody have therefore started. In the near future, these anti-cytokine therapies will become part of the standard armamentarium for the treatment of rheumatoid arthritis in Japan.

Journal

• Drug Delivery System

  Drug Delivery System 17 (1), 50-57, 2002

  THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM

Keywords

• monoclonal antibody
• rheumatoid arthritis
• TNF<I>α</I>
• anti-cytokine therapy
• infliximab

Details

• CRID: 1390001204640478080
• NII Article ID: 10008132059
• NII Book ID: AN10084591
• DOI: 10.2745/dds.17.50
• ISSN: 18812732
• ISSN: 09135006
• Web Site: https://search.jamas.or.jp/link/ui/2002170259
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed