Application of Enamel Matrix Derivative for Tooth Transplantation and Replantation.

• Hoshino Satoru

  The Second Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Tokyo Medical and Dental University

Bibliographic Information

Other Title

• 歯の移植・再植術へのエナメルマトリックス由来物質の応用

Abstract

Objective : The purpose of this study was to clarify the effects of enamel matrix proteins on the regeneration of periodontal ligament (PDL), during transplantation and replantation therapy.<BR>Materials and methods : [Exp 1] The crown and root apex of extracted dog teeth were removed and the remaining root separated longitudinally. Two-thirds of crownside PDL and cementum were removed. Prepared teeth were covered with propyleneglycol alginate (PGA) both with and without enamel matrix derivative (EMD) and cultured for 0-14 days. The outgrowth length of the tooth was measured and histological observation done. [Exp 2] The incisal teeth of adult dogs were extracted and 2/3 of crown side PDL and cementum removed. Prepared teeth were treated with PGA containing EMD (EMD group) . No tooth treatment was done in the control group. Following PGA treatment, teeth were replanted. The animals were sacrificed at 2 and 4 weeks after replantation and histological observation performed.<BR>Results : [Exp 1] The outgrowth length of the EMD group was longer than that of the other groups. The width of proliferated cell layer on the tooth in the EMD group was thicker. [Exp 2] Ankylosis surface of the EMD group was smaller than that of the control group. In the control group, the region of ankylosis increased longitudinally. In the EMD group, the newly-formed cementum was predominantly cellular cementum.<BR>Conclusion : The results suggested that enamel matrix protein enhance the regeneration of PDL and prevent tooth ankylosis in transplantation and replantation therapy.

Journal

• THE JOURNAL OF THE STOMATOLOGICAL SOCIETY,JAPAN

  THE JOURNAL OF THE STOMATOLOGICAL SOCIETY,JAPAN 67 (2), 133-145, 2000

  The Stomatological society, Japan

Keywords

• General Medicine

Details

• CRID: 1390282681318514688
• NII Article ID: 130004282911
• NII Article ID: 10008137642
• NII Book ID: AN00302674
• DOI: 10.5357/koubyou.67.133
• ISSN: 18845185
• ISSN: 03009149
• PubMed: 10921237
• Web Site: https://search.jamas.or.jp/link/ui/2001221285
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed