Ectopic Bone Induction in Recombinant Human Bone Morphogenetic Protein-2(rhBMP-2) Combined with Biphasic Calcium Phosphate(BCP).

DOI PubMed 33 References
  • Oda Shigeru
    Department of Periodontology, Faculty of Dentistry, Tokyo Medical and Dental University
  • Kinoshita Atsuhiro
    Department of Periodontology, Faculty of Dentistry, Tokyo Medical and Dental University
  • Higuchi Tatsuhiro
    Department of Periodontology, Faculty of Dentistry, Tokyo Medical and Dental University
  • Shizuya Toshio
    Department of Periodontology, Faculty of Dentistry, Tokyo Medical and Dental University
  • Ishikawa Isao
    Department of Periodontology, Faculty of Dentistry, Tokyo Medical and Dental University

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  • 二相性リン酸カルシウム（Ｂｉｐｈａｓｉｃ　Ｃａｌｃｉｕｍ　Ｐｈｏｓｐｈａｔｅ）を担体としたリコンビナントヒトＢＭＰ‐２（ｒｈＢＭＰ‐２）の異所性骨形成能について

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Abstract

The purpose of this study was to investigate the efficacy of BCP granules combined with rhBMP-2 for ectopic bone formation in rats. BCP granules were used as a carrier for rhBMP-2. The rhBMP-2 was adsorbed to BCP granules under the reduction of pressure. Twenty Wistar rats were used for this experiment and were divided into 4 groups according to the concentration (0, 2, 10, 50μg/700μl) of rhBMP-2implanted in each rat. The BMP and BCP complex was implant ed under the dorsal skin of the rats. Three weeks after the implantation, the rats were sacrificed. The experimental sites were immediately dissected and histological sections were prepared. In the 50μg group, new bone formation was observed in all rats, while bone tissue was not found in the 2μg and 0μg groups.<BR>These results indicated that BCP combined with rhBMP-2 could effectively induce ectopic bone formation. It was suggested that BCP granules alone could be applicable as a carrier for rhBMP-2 in order to induce new bone formation.

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