Ｓｕｌｆａｄｉｍｅｔｈｏｘｉｎｅ投与によるマウス胎仔の小下顎発現過程の観察

• 北村 敦

  東京医科歯科大学歯学部生体機能制御歯科学系顎顔面矯正学

書誌事項

タイトル別名

• Observation of Micrognathic Development in Mouse Fetus Induced by Sulfadimethoxine.

抄録

The purpose of this study was to investigate the process of micrognathic development in mouse fetus induced by Sulfadimethoxine (SDM) . SDM of 3, 000mg/kg was administered orally to pregnant ICR mice on days 8, 9, 10, 11, 12, and 13 of gestation. The fetuses were removed on day 15 to analyze the incidence of micrognathia. The incidence of micrognathia was the highest in the treated group on day 10. The fetuses, SDM-treated on day 10, were sacrificed on days 11, 12, 13, 14, 15, and 18 and prepared for histological and morphological analyses. Histomorphological analyses were performed by lateral and horizontal graphic reconstruction using serial frontal sections. It was also performed by clearing and alcian blue-alizarin red double staining. In the treated group, bilateral sigmoid buckling and shortening of Meckel's cartilage became evident after day 14, however, the nasal septal and capsule cartilage were less affected.<BR>It was concluded that remarkable hypoplastic and malformed Meckel's cartilage, caused by the administration of SDM, induced mandibular dysmorphogenesis.

収録刊行物

• 口腔病学会雑誌

  口腔病学会雑誌 65 (1), 25-41, 1998

  口腔病学会

キーワード

• General Medicine

詳細情報

• CRID: 1390001206343446144
• NII論文ID: 130004282838
• NII論文ID: 10008142996
• NII書誌ID: AN00302674
• DOI: 10.5357/koubyou.65.25
• ISSN: 18845185
• ISSN: 03009149
• PubMed: 9584419
• Web Site: https://search.jamas.or.jp/link/ui/1998175443
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可