三叉神経ニューロンにおける代謝調節型グルタミン酸受容体の薬理学的検討

• 成田 信一

  東京医科歯科大学歯学部歯科矯正学第一講座 日本医科大学薬理学教室

書誌事項

タイトル別名

• Pharmacological Study on Metabotropic Glutamate Receptors on Trigeminal Neurons.

抄録

Glutamic acid is known to be a major excitatory transmitter in the central nervous system. The nature of its receptors on the spinal motoneuron have been well investigated and elucidated to consist of ionotropic (iG1uR) as well as metabotropic glutamate receptors (mGluR) . However, the role of mG1uR on trigeminal motoneurons (TMN) and trigeminal sensory neurons (TSN), which play important roles in mastication, has not been well investigated. In this study, the nature of mG1uR on TMN and TSN was investigated using isolated brainstem preparations from neonatal rats. The activities of TMN and TSN were recorded from the trigeminal motor and sensory roots respectively, using a suction electrode. All iGluR agonists depolarized TMN and TSN. The mG1uR agonists used were RS-3, 5dihydroxyphenylglycine (RS-DHPG) for group I, (2S, 1'R, 2'R, 3'R) -2- (2, 3-Dicarboxycyclopropyl) glycine (DCG-IV) for group II, and L (+) -2-amino-4-phosphono-propinate (L-AP4) for group III. Whereas group I agonist increased spontaneous firing, groups II and III agonists decreased it. Group I agonist depolarized TMN and TSN directly. In contrast, groups II and III agonists hyperpolarized TSN but induced no potencial changes in TMN. These results suggested that mGluR exist on TMN and TSN.

収録刊行物

• 口腔病学会雑誌

  口腔病学会雑誌 65 (2), 233-240, 1998

  口腔病学会

キーワード

• General Medicine

詳細情報

• CRID: 1390001206342845056
• NII論文ID: 130004282850
• NII論文ID: 10008143671
• NII書誌ID: AN00302674
• DOI: 10.5357/koubyou.65.233
• ISSN: 18845185
• ISSN: 03009149
• PubMed: 9711041
• Web Site: https://search.jamas.or.jp/link/ui/1998248471
• 本文言語コード: ja
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