卵巣摘出ラットにおける上顎骨,下顎頭および大腿骨の構造変化に関する比較組織学的研究 A Comparative Histological Study on Structural Changes of Maxillae, Mandibular Condyles, and Femurs in Ovariectomized Rats

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著者

    • 石原 晃 ISHIHARA Akira
    • 昭和大学歯学部大学院歯学研究科冠橋義歯学専攻 Graduate School of Dentistry, Fixed Prosthodontics,School of Dentistry Showa University

抄録

Postmenopausal estrogen deficiency results in bone loss (osteoporosis) in humans and experimental animals. The acute and significant loss of trabecular bone in the ovariectomized (OVX) rat provides a useful experimental model of postmenopausal osteoporosis. Five months after ovariectomy of 3-month-old female rats, the mid and distal femurs, maxillae, and mandibular condyles were dissected and processed for light and backscattered electron microscopic examinations. Net trabecular bone values of femurs in OVX ats showed significant loss of trabecular (but not cortical) bones compared to those in sham-operated controls. Net bone volume in the maxillae of OVX rats was similar to that of controls. In mandibular condyles, OVX caused prominent bone loss similar to that in femurs. Throughout the observations, active osteoclastic bone resorption was rarely recognized, presumably due to the fact that the rats had been in the statistic post-OVX phase. These results suggested that, in this animal model of postmenopausal steoporosis, the bone loss is more prominent in trabecular bone areas formed by endochondral ossification such asmetaphyses of femurs and mandibular condyles than cortical bone areas formed by intramembranous ossification such as mid-diaphyses of femurs and maxillae.

収録刊行物

  • 日本補綴歯科學會雜誌 = The journal of the Japan Prosthodontic Society

    日本補綴歯科學會雜誌 = The journal of the Japan Prosthodontic Society 41(6), 934-944, 1997-12-10

    Japan Prosthodontic Society

参考文献:  29件中 1-29件 を表示

被引用文献:  3件中 1-3件 を表示

各種コード

  • NII論文ID(NAID)
    10008168001
  • NII書誌ID(NCID)
    AN00197911
  • 本文言語コード
    JPN
  • 資料種別
    ART
  • ISSN
    03895386
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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