ラットにおける加齢,咬合支持,飼料形態,栄養が全身に及ぼす影響 Histomorphometric, Immunohistochemical and Exercise-Phygiological Study on Age-, Tooth Loss-, Dietary- and Nutrition-related Changes in Rat Body

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著者

    • 平井 敏博 HIRAI Toshihiro
    • 北海道医療大学歯学部歯科補綴学第一講座 Department of Removable Prosthodontics,Health Sciences University of Hokkaido School of Dentistry
    • 池田 和博 IKEDA Yasuhiro
    • 北海道医療大学歯学部歯科補綴学第一講座 Department of Removable Prosthodontics,Health Sciences University of Hokkaido School of Dentistry
    • 橋川 美子 HASHIKAWA Yoshiko
    • 北海道医療大学歯学部歯科補綴学第一講座 Department of Removable Prosthodontics,Health Sciences University of Hokkaido School of Dentistry
    • 青木 聡 AOKI Satoru
    • 北海道医療大学歯学部歯科補綴学第一講座 Department of Removable Prosthodontics,Health Sciences University of Hokkaido School of Dentistry
    • 寺澤 秀朗 TERASAWA Hidero
    • 北海道医療大学歯学部歯科補綴学第一講座 Department of Removable Prosthodontics,Health Sciences University of Hokkaido School of Dentistry

抄録

In order to verify the influence of aging, tooth loss, and diet on bodily function, 216 old Donryu and Wistar male rats were divided into the following groups, the control group (fed solid diet), the soft diet group (fed powder diet containing the same components as solid one), the molarless group (all molars were removed at 45 weeks and then fed powder diet), the low calcium solid diet group (fed solid diet low in calcium and deficient in vitamin D) and the molarless low calcium diet group (all molars were removed at 45 weeks and then fed powder diet low in calcium and deficient in vitamin D). The histometric, exercise-physiologic, biochemical, and immunohistochemical analyses were performed.<BR>The results were as follows:<BR>1. The weight of the soft diet group at 75 weeks was higher than that of the control group at 75 weeks, showing statistical significance (p<0.01).<BR>2. The adrenal gland weight of the Donryu rats in the molarless group 4 weeks after extraction was higher than that of the control group, showing statistical significance (p<0.01).<BR>3. Occlusal support loss-and dietary-related changes were observed morphologically and histologically at the condyle and the attachment of the masseter muscle to mandible in addition to age-related changes.<BR>4. The endurance performance (exhaustion time during swimming) and the value of serum indices (creatine phosphokinase and free-fatty acid) after swimming in aged rats were considerably influenced by occlusal and masticatory alteration in addition to aging.<BR>5. The number of choline acetyltransferase (ChAT)-positive neurons in the nucleus of medial septal nucleus/nucleus diagonal of Broca of the molarless group showed decrease as compared to the control group and the soft diet group by immunohistochemical techniques. However, the number of neurons in the trigeminal motor nucleus showed no significant differences among the three groups.

収録刊行物

  • 日本補綴歯科學會雜誌 = The journal of the Japan Prosthodontic Society

    日本補綴歯科學會雜誌 = The journal of the Japan Prosthodontic Society 42(2), 175-183, 1998-04-10

    Japan Prosthodontic Society

参考文献:  57件中 1-57件 を表示

被引用文献:  3件中 1-3件 を表示

各種コード

  • NII論文ID(NAID)
    10008168880
  • NII書誌ID(NCID)
    AN00197911
  • 本文言語コード
    JPN
  • 資料種別
    REV
  • ISSN
    03895386
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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