歯科用血流画像化装置の開発

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  • Development of Laser Speckle Flowgraphy for Dental Research.

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Authors of previous studies suggested that the blood flow of denture supporting mucosa becomes an important index to evaluate the dentures, and a method to evaluate mucosal blood flow needs to be developed.<BR>The purpose of this study was to report a novel instrument (LSFD) for noninvasive, noncontact, and 2-dimensional measurement of mucosal microcirculation using the dynamic laser speckle effect, and to demonstrate that this instrument can detect an experimental change in palatal mucosal blood flow.<BR>Using LSFD, blood flow in five volunteers was measured before and after injecting 2% lidocaine containing 1/80, 000 epinephrine (0.2ml) into incisive papilla. LSFD offers a laser flowgram showing the 2-dimensional variation of the AD value, which is the quantitative index of the blood flow velocity, and the average AD (ADav, unit: AU) in the area of interest can be calculated. Thus the laser flowgrams were compared visually and ADav 100 s obtained from the incisive papilla region were compared quantitatively.<BR>As a result, the changes showing local anemia around the injection site were visualized, and the ADav 100 after injection (56.4±4.6) was significantly decreased (p<0.01, paired t-test) in comparison with that before injection (100.2±9.3).<BR>These findings suggested that LSFD can detect the change in palatal mucosal blood flow. Therefore, LSFD may be applied to evaluate the blood flow of denture supporting mucosa and dentures.

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