空間記憶学習能の評価に用いる各種迷路装置の検討 Evaluation of Two Types of Mazes on Spatial Learning and Memory in Mice

この論文にアクセスする

この論文をさがす

著者

    • 田中 久敏 TANAKA Hisatoshi
    • 岩手医科大学歯学部歯科補綴学第一講座 Department of Removable Prosthodontics, School of Dentistry, Iwate Medical University
    • 虫本 栄子 MUSHIMOTO Eiko
    • 岩手医科大学歯学部歯科補綴学第一講座 Department of Removable Prosthodontics, School of Dentistry, Iwate Medical University
    • 千葉 晃 CHIBA Akira
    • 岩手医科大学歯学部歯科補綴学第一講座 Department of Removable Prosthodontics, School of Dentistry, Iwate Medical University
    • 岩渕 安信 IWABUCHI Yasunobu
    • 岩手医科大学歯学部歯科補綴学第一講座 Department of Removable Prosthodontics, School of Dentistry, Iwate Medical University

抄録

The purpose of this study was to compare the effectiveness of two types of mazes, multiple maze and 8-arm radial maze, in relation to age and sex difference, onthe acquisition of spatial learning and memory in mice, in addition to estimating memory retention.<BR>Three groups of male and female ddY mice were used: 4 weeks old (Young group), 7 weeks old (Adult group), and 82 weeks old (Aged group).Spatial learning and memory were measured by performance in both mazes.<BR>Differences between search times and the error rate study in all groups could not be detected in the multiple maze acquisition. Furthermore, a study using a simplified multiple maze showed that there was no significant difference between groups during memory retention tasks.<BR>As for search times using an 8-arm radial maze, the aged group showed significantly slower time compared to other groups, and the aged female group showed significantly slower time compared to the aged malegroup, but these results were not in accordance with the error rate. However, studies using the 8-arm radial maze could show data that aged groups and female mice experienced decreased memory retention compared to other groups.<BR>The present study confirmed that an 8-arm radial maze could be helpful in the retention of spatial learning and memory.

収録刊行物

  • 日本補綴歯科學會雜誌 = The journal of the Japan Prosthodontic Society

    日本補綴歯科學會雜誌 = The journal of the Japan Prosthodontic Society 43(2), 363-372, 1999-04-10

    Japan Prosthodontic Society

参考文献:  27件中 1-27件 を表示

被引用文献:  4件中 1-4件 を表示

各種コード

  • NII論文ID(NAID)
    10008173021
  • NII書誌ID(NCID)
    AN00197911
  • 本文言語コード
    JPN
  • 資料種別
    ART
  • ISSN
    03895386
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
ページトップへ