Bradykinin antagonist: Current status and perspective.
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- HIRAYAMA Yoshitaka
- Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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- KAYAKIRI Hiroshi
- Medicinal Chemistry Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
Bibliographic Information
- Other Title
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- ブラジキニン受容体きっ抗薬の開発現況と今後の展開
- 新薬開発状況 ブラジキニン受容体拮抗薬の開発現況と今後の展開
- シンヤク カイハツ ジョウキョウ ブラジキニン ジュヨウタイ キッコウヤク ノ カイハツ ゲンキョウ ト コンゴ ノ テンカイ
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Abstract
The kallikrein-kinin system plays an important role in many physiological and pathophysiological conditions such as homeostasis of circulation, inflammation/allergy, pain, shock, etc. Two types of kinin receptor are known, bradykinin (BK) B1 receptor and BK B2 receptor. B2 receptors are constitutively expressed and mediate most physiological actions of kinins, whereas B1 receptors are highly inducible upon inflammatory stimulation or tissue injury, suggesting that they are involved in inflammation and/or nociception. Only three peptide type B2 antagonists, NPC 567, CP-0127 and HOE-140, have been evaluated in clinical studies so far, and some beneficial effects of B2 antagonists have been shown for rhinitis, asthma, systemic inflammatory response syndrome/sepsis and brain injury. However, the results were less convincing than expected. Now several potent and orally active nonpeptide B2-receptor antagonists have been found, which are expected to overcome the weak point of the peptide type antagonists and clarify the therapeutic potential of the B2-receptor antagonist for novel indications as well as those mentioned above. As for B1 receptors, no antagonist has been tested in a clinical trial. The important role of B1 receptors is just being elucidated by use of peptide type antagonists or B1 receptor gene knockout mice. The further development of newer B1 antagonists and clinical evaluation is desired.<br>
Journal
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- Folia Pharmacologica Japonica
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Folia Pharmacologica Japonica 119 (1), 45-53, 2002
The Japanese Pharmacological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390001204270382336
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- NII Article ID
- 10008181757
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- NII Book ID
- AN00198335
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- COI
- 1:STN:280:DC%2BD387islGktg%3D%3D
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- ISSN
- 13478397
- 00155691
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- NDL BIB ID
- 6026847
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- PubMed
- 11862756
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed