脳虚血・再灌流と脳細胞応答 Dynamic cellular response following brain ischemia and reperfusion

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著者

    • 松本 昌泰 MATSUMOTO Masayasu
    • 大阪大学医学部第一内科・神経内科学教室 First Department of Medicine and Department of Neurology, Osaka University Medical School

抄録

Since the first documentation of the induction of heat shock protein following transient cerebral ischemia, much experimental evidence suggested that all of the cellular elements in the central nervous system show dynamic stress responses depending on the degree of environmental changes induced by ischemia and reperfusion. In this review, first 1 focused on the importance of the usage of an appropriate experimental model for brain ischemia and reperfusion, and I presented our work on mouse models of transient global and focal ischemia. Next, I reviewed the pathogenic role of microvascular stasis (i.e., secondary ischemia) caused by the primary ischemic event and demonstrated the important role of cell adhesion molecules through the experiments using ICAM-1 knock-out mouse as a model of brain ischemia/reperfusion. Thirdly, I discussed the ischemia-induced neuronal cell responses in relation to the apoptosis-like selective neuronal death and the induction of adopted stress responses including stress protein synthesis and 'ischemic tolerance' phenomenon. A variety of stress proteins induced by ischemic stress have been reviewed and a pivotal role of tyrosine kinase system in selective neuronal death has been suggested in the gerbil model of transient forebrain ischemia. Finally, I showed the important pathophysiological roles of glial cells such as astrocytes and oligodendrocytes in the celluar cross-talk triggered by an ischemic event. For the development of a novel therapeutic agent against ischemic stroke, it is quite important to clarify both the negative and positive cellular responses induced by brain ischemia/reperfusion.

収録刊行物

  • 日本薬理学雑誌

    日本薬理学雑誌 111(1), 3-12, 1998-01-01

    公益社団法人 日本薬理学会

参考文献:  49件中 1-49件 を表示

被引用文献:  1件中 1-1件 を表示

各種コード

  • NII論文ID(NAID)
    10008181841
  • NII書誌ID(NCID)
    AN00198335
  • 本文言語コード
    JPN
  • 資料種別
    REV
  • ISSN
    00155691
  • NDL 記事登録ID
    4382492
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z19-247
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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