書誌事項
- タイトル別名
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- Stress and Redox Regulation. Heat shock response in a rat model of septic multiple organ dysfunction syndrome.
- ハイケツショウセイ タゾウキ キノウ ショウガイ ニ オケル ストレス オウトウ
- ストレスと細胞応答
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Severe sepsis is known to result in multiple organ dysfunction syndrome (MODS), which is thought to be mediated by oxidative stress, as a result of excessive systemic inflammation. Heme Oxygenase-1 (HO-1), the rate limiting enzyme in heme catabolism, is also known as HSP32. HO-1 is induced not only by its substrate heme but also by oxidative stress. We investigated gene expression of HO-1 and physiological significance of HO-1 induction in a rat model of septic MODS induced by intraperitoneal injection of bacterial lipopolysaccharide (LPS). Following administration of LPS, HO-1 mRNA was significantly induced in the liver, lung and kidney in an organ-specific manner. Hepatic HO-1 induction appears to be mediated by an increase in hepatic free heme concentration. Inhibition of HO-1 activity by tin mesoporphyrin significantly exacerbated lung injury. These results suggest that HO-1 induction may play an important role in conferring protection on cells from oxidative damage not only by catalyzing heme, a pro-oxidant, but also by producing bilirubin, an anti-oxidant. Furthermore, HO-1 mRNA is induced markedly in the buffy coat of the blood at 3 h after LPS administration, coinciding with the increase in serum IL-6 level, suggesting that HO-1 may be one of the key markers of septic MODS.
収録刊行物
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- 日本薬理学雑誌
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日本薬理学雑誌 114 (5), 295-302, 1999
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390282679249117312
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- NII論文ID
- 10008182347
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- NII書誌ID
- AN00198335
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- COI
- 1:CAS:528:DyaK1MXntFansr0%3D
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- ISSN
- 13478397
- 00155691
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- NDL書誌ID
- 4887355
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- PubMed
- 10621943
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可