Perivascular Purinergic Nerve-Induced Vasoconstrictions in Canine Isolated Splenic Arteries.

• Yang Xiao-Ping

  Department of Pharmacology,Shinshu University School of Medicine,Matsumoto 390-8621,Japan

• Chiba Shigetoshi

  Department of Pharmacology,Shinshu University School of Medicine,Matsumoto 390-8621,Japan

抄録

We tried to induce selective perivascular purinergic nerve stimulation in isolated canine splenic arterial preparations, using the cannula insertion method.Under the conditions of periarterial electrical stimulation(ES), i.e., trains of 1, 3 and 10 pulses, 1−ms pulse duration and 10−V amplitude at 1 Hz, monophasic vasoconstriction was consistently induced.The ES−induced vasoconstriction was not influenced by prazosin in doses that completely inhibited noradrenaline−induced vasoconstrictions, but it was suppressed by α, β−methylene ATP, a P2X purinoceptor desensitizer.Thus, it is indicated that a selective purinergic transmitter release is readily obtained in the isolated splenic arterial preparation.

収録刊行物

• Jpn.J.Pharmacol.

  Jpn.J.Pharmacol. 82 (1), 71-73, 2000

  公益社団法人 日本薬理学会

キーワード

• Dog splenic artery
• Perivascular electric stimulation
• P2X Purinoceptor

詳細情報

• CRID: 1390282679263813632
• NII論文ID: 10008182766
• NII書誌ID: AA00691188
• DOI: 10.1254/jjp.82.71
• COI: 1:CAS:528:DC%2BD3cXotF2rsg%3D%3D
• ISSN: 13473506
• ISSN: 00215198
• NDL書誌ID: 4966497
• PubMed: 10874592
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4966497
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819307310?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819307310?httpAccept=text/plain
• Web Site: https://www.jstage.jst.go.jp/article/jjp/82/1/82_1_71/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2000147974
• 本文言語コード: en
• データソース種別:
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