Characterization of Protease-Activated Receptors in Rat Peritoneal Mast Cells.

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  • Nishikawa Hiroyuki
    Research & Development Center,Fuso Pharmaceutical Industries Ltd.,2-3-11 Morinomiya,Jotoh-ku,Osaka 536-8523,Japan
  • Kawabata Atsufumi
    Department of Pathophysiology & Therapeutics,Faculty of Pharmaceutical Sciences,Kinki University,3-4-1 Kowakae,Higashi-Osaka 577-8502,Japan
  • Kuroda Ryotaro
    Department of Pathophysiology & Therapeutics,Faculty of Pharmaceutical Sciences,Kinki University,3-4-1 Kowakae,Higashi-Osaka 577-8502,Japan
  • Nishida Minoru
    Research & Development Center,Fuso Pharmaceutical Industries Ltd.,2-3-11 Morinomiya,Jotoh-ku,Osaka 536-8523,Japan
  • Kawai Kenzo
    Research & Development Center,Fuso Pharmaceutical Industries Ltd.,2-3-11 Morinomiya,Jotoh-ku,Osaka 536-8523,Japan

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抄録

Activation of protease−activated receptor(PAR)−1 or PAR−2 elicits inflammation most probably via mast cell degranulation in vivo.The present study aimed at characterizing PARs in rat peritoneal mast cells(PMC).Messenger RNA for PAR−1, but not for PAR−2, was detected in PMC.Thrombin, the PAR−1 agonist SFLLR−NH2 or the PAR−2 agonist SLIGRL−NH2 failed to induce histamine release from PMC.Surprisingly, the PAR−2−inactive control peptide LSIGRL−NH2 triggered histamine release from PMC.Thus, PAR−1, but not PAR−2, are expressed in PMC, whereas neither PAR−1 nor PAR−2 are considered to be involved in degranulation of PMC.LSIGRL−NH2 does not appear to be appropriate as a control peptide for PAR−2 in inflammation studies.

収録刊行物

  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 82 (1), 74-77, 2000

    公益社団法人 日本薬理学会

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