Peroxynitrite-Generating Species: Good Candidate Oxidants in Aqueous Extracts of Cigarette Smoke

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抄録

Cigarette smoking is a well−known risk factor for atherosclerosis, but the mechanism of the adverse biological effect of smoking remains to be established.Cigarette smoke contains high concentrations of free radicals and oxidants.We show here that cigarette smoke extracts(CSE), prepared by bubbling the gas phase of smoke into phosphate−buffered saline, could convert tyrosine to 3−nitrotyrosine.The tyrosine nitration terminated 6 h after incubating tyrosine with CSE at 37°C.These results indicate that the active oxidants in CSE are peroxynitrite−generating species like 3−morpholinosydnonimine(SIN−1), suggesting that they modify plasma lipoproteins and contribute to the pathogenesis of atherosclerosis.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 82(1), 78-81, 2000-01-01

    公益社団法人 日本薬理学会

参考文献:  15件中 1-15件 を表示

被引用文献:  4件中 1-4件 を表示

各種コード

  • NII論文ID(NAID)
    10008182795
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    4966515
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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