Phenytoin and Its Metabolite,5-(4-Hydroxyphenyl)-5-Phenylhydantoin,Show Bone Resorption in Cultured Neonatal Mouse Calvaria

• Takahashi Atsushi

  Department of Pharmacology,Tohoku University School of Dentistry,Sendai 980-8575,Japan Department of Pediatric Dentistry,Tohoku University School of Dentistry,Sendai 980-8575,Japan

• Onodera Kenji

  Department of Pharmacology,Tohoku University School of Dentistry,Sendai 980-8575,Japan

• Shinoda Hisashi

  Department of Pharmacology,Tohoku University School of Dentistry,Sendai 980-8575,Japan

• Mayanagi Hideaki

  Department of Pediatric Dentistry,Tohoku University School of Dentistry,Sendai 980-8575,Japan

書誌事項

タイトル別名

• Phenyioin and Its Metabolite, 5-(4-Hydroxyphenyl)-5-Phenylhydantoin, Show Bone Resorption in Cultured Neonatal Mouse Calvaria.

抄録

The effects of phenytoin and its major metabolite, 5−(4−hydroxyphenyl)−5−phenylhydantoin(HPPH), on bone resorption of neonatal mouse calvaria were examined in vitro.Both phenytoin and HPPH induced significant bone resorption as compared to the controls after 72 h in culture.This effect may be the cause of phenytoin−induced bone loss in vivo.

収録刊行物

• Jpn.J.Pharmacol.

  Jpn.J.Pharmacol. 82 (1), 82-84, 2000

  公益社団法人 日本薬理学会

キーワード

• Phenytoin
• Calvaria
• Bone resorption

詳細情報

• CRID: 1390282679263814912
• NII論文ID: 10008182811
• NII書誌ID: AA00691188
• DOI: 10.1254/jjp.82.82
• COI: 1:CAS:528:DC%2BD3cXotF2rsQ%3D%3D
• ISSN: 13473506
• ISSN: 00215198
• NDL書誌ID: 4966527
• PubMed: 10874595
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4966527
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819307346?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819307346?httpAccept=text/plain
• Web Site: https://www.jstage.jst.go.jp/article/jjp/82/1/82_1_82/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2000142165
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
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